Comparison of Methods To Collect Fecal Samples for Microbiome Studies Using Whole-Genome Shotgun Metagenomic Sequencing
Doratha A. Byrd, Rashmi Sinha, Kristi L. Hoffman, Jun Chen, Xing Hua, Jianxin Shi, Nicholas Chia, Joseph F. Petrosino, Emily Vogtmann
Abstract
A major direction for future microbiome research is implementation of fecal sample collections in large-scale, prospective epidemiologic studies. Studying microbiome-disease associations likely requires microbial data to be pooled from multiple studies. Our findings suggest collection methods that are most optimal to be used standardly across future WGSS microbiome studies.
Topics & Concepts
MetagenomicsMicrobiomeShotgun sequencingBiologyComputational biologyFecesShotgunGenomeBioinformaticsGeneticsMicrobiologyGeneGut microbiota and healthColorectal Cancer Screening and DetectionClostridium difficile and Clostridium perfringens research