Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions
Roman Mehling, Johannes Schwenck, Christina Lemberg, Christoph Trautwein, Laimdota Zizmare, Daniela Kramer, Anne Müller, Birgit Fehrenbacher, Irene González-Menéndez, Leticia Quintanilla‐Martínez, Katrin Schröder, Ralph P. Brandes, Martin Schaller, Wolfram Ruf, Martin Eichner, Kamran Ghoreschi, Martin Röcken, Bernd J. Pichler, Manfred Kneilling
Abstract
MPO and NOX2 are the dominant sources of ROS/RNS in acute and chronic DTHR. Nevertheless, depletion of one primary source of ROS/RNS exhibited only marginal but conflicting impact on acute and chronic cutaneous DTHR. Thus, ROS/RNS are not a single entity, and each species has different properties at certain stages of the disease, resulting in different outcomes.
Topics & Concepts
Reactive nitrogen speciesReactive oxygen speciesImmunologyHypersensitivity reactionChemistryOxygenInflammationMedicineBiochemistryOrganic chemistryNeutrophil, Myeloperoxidase and Oxidative MechanismsDermatology and Skin DiseasesImmune Response and Inflammation