Proteomic Network of Antibiotic-Induced Outer Membrane Vesicles Released by Extensively Drug-Resistant Elizabethkingia anophelis
Ming‐Hsien Chiang, Fang-Ju Chang, Dinesh Kumar Kesavan, Aparna Vasudevan, Huaxi Xu, Kuo-Lun Lan, Shu-Wei Huang, Hung‐Sheng Shang, Yi‐Ping Chuang, Ya‐Sung Yang, Te-Li Chen
Abstract
Elizabethkingia anophelis is a bacterium often associated with nosocomial infection. This study demonstrated that imipenem-induced E. anophelis outer membrane vesicles (OMVs) are immunologically relevant and crucial for bacterial survival under antibiotic stress conditions rather than being a source of antibiotic resistance.
Topics & Concepts
Bacterial outer membraneMicrobiologyBiologyProteomeImipenemAntibioticsBacteriaMultiple drug resistanceDrug resistanceAntibiotic resistanceGeneBiochemistryGeneticsEscherichia coliInfections and bacterial resistanceStreptococcal Infections and TreatmentsBacterial biofilms and quorum sensing