Progress in the drug encapsulation of poly(lactic-<i>co</i>-glycolic acid) and folate-decorated poly(ethylene glycol)–poly(lactic-<i>co</i>-glycolic acid) conjugates for selective cancer treatment
Jagan Mohan Dodda, Tomáš Remiš, Emmanuel Rotimi Sadiku, Yi‐Cheun Yeh
Abstract
-glycolic acid) (FA-PEG-PLGA) conjugates are discussed, along with several representative examples. Particularly, the reactions used for preparing drug-conjugated PLGA and FA-PEG-PLGA are emphasized, with the associated chemistries involved in the formation of structures and their biocompatibility with internal organs. This review provides a deeper understanding of the constituents and interactions of PLGA-conjugated materials to ensure successful conjugation in PLGA material design and the subsequent biomedical applications.
Topics & Concepts
Glycolic acidLactic acidEthylene glycolDrugMaterials scienceDrug deliveryPharmacologyChemistryMedicineOrganic chemistryNanotechnologyBiologyGeneticsBacteriaNanoparticle-Based Drug Deliverybiodegradable polymer synthesis and propertiesGraphene and Nanomaterials Applications