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Discovery of thirteen cobalt(<scp>ii</scp>) and copper(<scp>ii</scp>) salicylaldehyde Schiff base complexes that induce apoptosis and autophagy in human lung adenocarcinoma A549/DDP cells and that can overcome cisplatin resistance <i>in vitro</i> and <i>in vivo</i>

Ya-Ting Chen, Shaonan Zhang, Shaonan Zhang, Zhenfeng Wang, Qing-Min Wei, Shu-Hua Zhang, Shu-Hua Zhang

2022Dalton Transactions47 citationsDOI

Abstract

Compared with 1–9, 10–13 displayed stronger cytotoxic activities against the tested A549/DDP cells. 11 and 13 could induce apoptosis and autophagy in A549/DDP cells and exhibited pronounced and selective activity against A549/DDP xenografts in vivo .

Topics & Concepts

SalicylaldehydeSchiff baseChemistryApoptosisAutophagyA549 cellCopperStereochemistryBiochemistryOrganic chemistryMetal complexes synthesis and propertiesMetal-Organic Frameworks: Synthesis and ApplicationsFerrocene Chemistry and Applications
Discovery of thirteen cobalt(<scp>ii</scp>) and copper(<scp>ii</scp>) salicylaldehyde Schiff base complexes that induce apoptosis and autophagy in human lung adenocarcinoma A549/DDP cells and that can overcome cisplatin resistance <i>in vitro</i> and <i>in vivo</i> | Litcius