Methods and Limitations of Augmenting Mesenchymal Stem Cells for Therapeutic Applications
Carlos Theodore Huerta, Yulexi Y. Ortiz, Zhaojun Liu, Omaida C. Velázquez
Abstract
Unmodified MSCs have demonstrated only modest benefits in many preclinical and clinical studies due to issues with cell engraftment, viability, heterogeneity, and immunocompatibility between donor and recipient. Furthermore, unmodified MSCs can have low inherent therapeutic potential for which intensive research over the past few decades has been dedicated to improving cell functionality and potency.
Topics & Concepts
Mesenchymal stem cellRegenerative medicineCell therapyEpigeneticsStem-cell therapyIn vivoStem cellComputational biologyMedicineImmune systemBioinformaticsBiologyImmunologyBiotechnologyCell biologyPathologyGeneBiochemistryMesenchymal stem cell researchTissue Engineering and Regenerative MedicineElectrospun Nanofibers in Biomedical Applications