Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors
Fumihito Ushiyama, Hideaki Amada, Yasuhiro Mihara, Tomoki Takeuchi, Nozomi Tanaka-Yamamoto, Masashi Mima, M. Kamitani, Reiko Wada, Yunoshin Tamura, Mayumi Endo, Aiko Masuko, Iichiro Takata, Kosuke Hitaka, Hiroyuki Sugiyama, Norikazu Ohtake
Topics & Concepts
ChemistryLead compoundMicrobiologyStaphylococcus aureusPenicillinStreptococcus pneumoniaeAntibioticsMultiple drug resistanceTopoisomerase IVAntibacterial activityBacteriaDNA gyraseEscherichia coliBiologyBiochemistryIn vitroGeneGeneticsCancer therapeutics and mechanismsAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and Efficacy