Electrochemical Sulfonylation/Cyclization of <i>N</i>-Alkenylacrylamides with Sodium Sulfinates or Sulfonyl Hydrazides
Zhixian Yang, Lu-Cai Ding, Gui-Hong Yang, Dongyin Wang, Lou Shi, Yanni Li, Deqiang Liang
Abstract
Two general protocols for the regioselective electrochemically enabled sulfonylation cyclization of N -alkenylacrylamides with sodium sulfinates or sulfonyl hydrazides were described. These methods were carried out under mild, chemical oxidant-free, and transition-metal-free conditions with a broad substrate scope and good functional group tolerance to provide sulfonyl-containing 4-pyrrolin-2-ones, which is readily scalable to the gram scale.
Topics & Concepts
ChemistrySulfonylElectrochemistrySodiumOrganic chemistryMedicinal chemistryCombinatorial chemistryElectrodeAlkylPhysical chemistrySulfur-Based Synthesis TechniquesRadical Photochemical ReactionsChemical Synthesis and Reactions