Peripheral Nerve Injury Induced by Japanese Encephalitis Virus in C57BL/6 Mouse
Huan Yang, Xiaoli Wang, Zhao Wang, Zhao Wang, Guowei Wang, Shihong Fu, Fan Li, Liping Yang, Yanping Yuan, Kaichun Shen, Huanyu Wang, Zhenhai Wang, Zhenhai Wang
Abstract
family and causes high mortality and disability rates. It invades the central nervous system and induces acute inflammatory injury and neuronal death. Thus, JEV infection is a major global public health concern. Previously, motor dysfunction was mainly attributed to central nervous system damage. Our knowledge regarding JEV-induced PNI is vague and neglected. Therefore, a laboratory animal model is essential. Herein, we showed that C57BL/6 mice can be used to study JEV-induced PNI through multiple approaches. We also demonstrated that viral loads might be positively correlated with lesion severity. Therefore, inflammation and direct virus infection may be the putative mechanisms underlying JEV-induced PNI. The results of this study laid the foundation for further elucidation of the pathogenesis mechanisms of PNI caused by JEV.