Human Metapneumovirus Phosphoprotein Independently Drives Phase Separation and Recruits Nucleoprotein to Liquid-Like Bodies
Kerri Beth Boggs, Kearstin Edmonds, Nicolás Cifuentes-Muñoz, Farah El Najjar, Conny Ossandón, McKenna Roe, Chao Wu, Carole L. Moncman, Trevor P. Creamer, Gaya K. Amarasinghe, Daisy W. Leung, Rebecca Dutch
Abstract
Human metapneumovirus (HMPV) is a leading cause of respiratory disease among children, immunocompromised individuals, and the elderly. Currently, no vaccines or antivirals are available for the treatment of HMPV infections.
Topics & Concepts
Human metapneumovirusMetapneumovirusPhosphoproteinVirologyNucleoproteinMedicineImmunologyBiologyRespiratory systemRespiratory tract infectionsVirusPhosphorylationInternal medicineGeneticsRespiratory viral infections researchRNA modifications and cancerCryospheric studies and observations