Proteogenomics reveals sex-biased aging genes and coordinated splicing in cardiac aging
Yu Han, Sara A. Wennersten, Julianna M. Wright, R W Ludwig, Edward Lau, Maggie P. Y. Lam
Abstract
Han et al. used proteogenomics to compare male and female mouse hearts at 4 and 20 mo. Sex-biased cardiac genes function in mitochondrial metabolism, translation, autophagy, and other processes. Hundreds of cardiac genes show sex-by-age interactions, that is, sex-biased aging genes. Cardiac aging is accompanied with a remodeling of exon usage in functionally coordinated genes, concomitant with differential expression of RNA-binding proteins and splice factors. These features represent an underinvestigated aspect of cardiac aging that may be relevant to the search for disease mechanisms.
Topics & Concepts
BiologyAlternative splicingGeneTranscriptomeRNA splicingSexual dimorphismProteogenomicsExonGene expressionGeneticsProteomicsProteomeRNA-SeqRNAComputational biologyEndocrinologyRNA Research and SplicingRNA modifications and cancerRNA and protein synthesis mechanisms