Nano-enzyme hydrogels for cartilage repair effectiveness based on ternary strategy therapy
Wei Deng, Yue Zhou, Qinlin Wan, Lei Li, Hui Deng, Yong Yin, Qingsong Zhou, Qiujiang Li, Duo Cheng, Xuefeng Hu, Yunbing Wang, Ganjun Feng
Abstract
An artificial nano-enzyme-enhanced hydrogel was developed to treat OA through a ternary synergistic strategy of efficiently driving O 2 production from endogenous ROS in chondrocytes and maintaining lubrication at the articular cartilage interface.
Topics & Concepts
Self-healing hydrogelsTernary operationMaterials scienceNano-CartilageNanotechnologyComposite materialMedicineComputer sciencePolymer chemistryAnatomyProgramming languageOsteoarthritis Treatment and MechanismsChemokine receptors and signalingSilk-based biomaterials and applications