The role of voltage-gated calcium channels in the pathogenesis of Parkinson’s disease
Alejandro Sandoval, Paz Duran, Alejandra Corzo-López, Miriam Fernández-Gallardo, David Muñoz-Herrera, Margarita Leyva-Leyva, Ricardo González‐Ramírez, Ricardo Felix
Abstract
channels in PD and discuss some novel aspects of channel regulation and its impact on the molecular pathophysiology of the disease. an exhaustive search of the literature in the field was carried out using the PubMed database of The National Center for Biotechnology Information. Systematic searches were performed from the initial date of publication to May 2022. channels could play a fundamental role in the pathogenesis of PD and, as such, could be a potentially attractive target for therapeutic intervention. channels will provide a framework to understand better the neurodegenerative processes that occur in PD and a possible path toward identifying new therapeutic targets to treat this condition.