The Cystic Fibrosis Upper and Lower Airway Metagenome
Katarzyna Pienkowska, Marie‐Madlen Pust, Margaux Gessner, Svenja Gaedcke, Ajith Thavarasa, Ilona Rosenboom, Patricia Morán Losada, Rebecca Minso, Christin Arnold, Silke Hedtfeld, Marie Dorda, Lutz Wiehlmann, Jochen G. Mainz, Jens Klockgether, Burkhard Tümmler
Abstract
Cystic fibrosis (CF) is the most common life-limiting monogenetic disease in European populations and is caused by mutations in the CFTR gene. Chronic airway infections with opportunistic pathogens are the major morbidity that determines prognosis and quality of life in most people with CF.
Topics & Concepts
SputumCystic fibrosisMetagenomicsMicrobiologyBiologyStenotrophomonas maltophiliaMicrobiomeStenotrophomonasStaphylococcus epidermidisPseudomonas aeruginosaShotgun sequencingStaphylococcus aureusMedicineDNA sequencingBacteriaGeneticsPseudomonasPathologyGeneTuberculosisCystic Fibrosis Research AdvancesTracheal and airway disordersPediatric health and respiratory diseases