The NMDA receptor subunit GluN3A regulates synaptic activity-induced and myocyte enhancer factor 2C (MEF2C)-dependent transcription
Liangfu Chen, Michelle R. Lyons, Fang Liu, Matthew V. Green, Nathan G. Hedrick, Ashley B. Williams, Arthy Narayanan, Ryohei Yasuda, Anne E. West
Abstract
). Our evidence that GluN3A regulates MEF2C-dependent transcription reveals a novel mechanism by which NMDAR subunit composition confers specificity to the program of synaptic activity-regulated gene transcription in developing neurons.
Topics & Concepts
Mef2MEF2CNMDA receptorTranscription factorEnhancerCell biologyProtein subunitChemistryAMPA receptorBiologyReceptorBiochemistryGeneNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanismsGenetics and Neurodevelopmental Disorders