NADPH-Independent Inactivation of CYP2B6 and NADPH-Dependent Inactivation of CYP3A4/5 by PBD: Potential Implication for Assessing Covalent Modulators for Time-Dependent Inhibition
Mika Kosaka, Donglu Zhang, Simon Wong, Zhengyin Yan
Topics & Concepts
ChemistryCYP3A4Covalent bondDose dependenceCYP2B6PharmacologyBiochemistryEnzymeCytochrome P450BiophysicsBiologyEndocrinologyOrganic chemistryPharmaceutical studies and practicesClick Chemistry and ApplicationsPharmacogenetics and Drug Metabolism