Synthesis of Saturated N‐Heterocycles via a Catalytic Hydrogenation Cascade
Tobias Wagener, Marco Pierau, Arne Heusler, Frank Glorius
Abstract
Saturated N-heterocycles are prominent motifs found in various natural products and pharmaceuticals. Despite the increasing interest in this class of compounds, the synthesis of saturated bicyclic azacycles requires tedious multi-step syntheses. Herein, we present a one-pot protocol for the synthesis of octahydroindoles, decahydroquinolines, and octahydroindolizines through a cascade reaction.
Topics & Concepts
ChemistryCascadeCatalysisBicyclic moleculeCombinatorial chemistryCascade reactionOrganic chemistryChromatographyAsymmetric Hydrogenation and CatalysisSurface Chemistry and CatalysisCatalytic C–H Functionalization Methods