Dynamic kinetic resolution of atropisomeric <i>N</i>-arylindoles <i>via</i> chiral <i>N</i>-triflyl phosphoramide catalyzed asymmetric reductive amination
You‐Dong Shao, Dandan Han, Hongxin Jiang, Xinyu Zhou, Weikang Wang, Jiaxi Zhang, Yafei Liu, Dao‐Juan Cheng
Abstract
The first organocatalyzed asymmetric reductive amination towards axially chiral N -arylindoles proceeding through n → π* interaction-induced dynamic kinetic resolution is reported.
Topics & Concepts
Kinetic resolutionChemistryReductive aminationAminationCatalysisKinetic energyCombinatorial chemistryOrganic chemistryMedicinal chemistryEnantioselective synthesisPhysicsQuantum mechanicsAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityAsymmetric Synthesis and Catalysis