SDC1-TGM2-FLOT1-BHMT complex determines radiosensitivity of glioblastoma by influencing the fusion of autophagosomes with lysosomes
Liang Zeng, Zheng Wang, Xinglong Liu, Yuchuan Zhou, Xiaoya Jin, Yuqi Xiao, Yang Bai, Yan Pan, Jianghong Zhang, Chunlin Shao
Abstract
The SDC1-TGM2-FLOT1-BHMT copolymer, a novel member of the protein complexes involved in the fusion of lysosomes and autophagosomes, maintained the autophagic flux in the irradiated tumor cells and ultimately enhanced radioresistance of GBM, which provides new insights of the molecular mechanism and therapeutic targets of radioresistant GBM.
Topics & Concepts
RadioresistanceAutophagyCancer researchBiologyRadiosensitivityCell biologyRadiation therapyApoptosisCell cultureMedicineBiochemistryGeneticsInternal medicineLipid metabolism and disordersAutophagy in Disease and TherapyCaveolin-1 and cellular processes