Development of MDM2 degraders based on ligands derived from Ugi reactions: Lessons and discoveries
Bo Wang, Jin Liu, Ira Tandon, Suzhen Wu, Peng Teng, Jianhua Liao, Weiping Tang
Topics & Concepts
ChemistryMdm2Ubiquitin ligaseProteolysisDNA ligaseUbiquitinCell growthComputational biologyBiochemistryCell biologyCombinatorial chemistryApoptosisEnzymeBiologyGeneProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways