Methylated <i>SFRP2</i> and<i> SDC2</i> in stool specimens for Colorectal Cancer early detection: A cost-effective strategy for Chinese population
Guodong Zhao, Xiaoyu Liu, Yi Liu, Yong Ma, Jun Yang, Hui Li, Shangmin Xiong, Sujuan Fei, Minxue Zheng, Xiangwei Zhao
Abstract
The aim of this study was to evaluate the feasibility of combination of methylated SFRP2 and methylated SDC2 (SpecColon test) in stool specimens for colorectal cancer (CRC) early detection and to optimize the cut-off value of methylated SFRP2 and methylated SDC2. Methods: Approximately 5 g of stool specimen each was collected from 420 subjects (291 in the training cohort and 129 in the validation cohort). Stool DNA was extracted and bisulfite-converted, followed by detection of methylated level of SFRP2 and SDC2. Youden index was employed to determine the cut-off value.
Topics & Concepts
Colorectal cancerMedicineInternal medicineChinese populationGastroenterologyPopulationOncologyCancerBiologyGeneticsEnvironmental healthGenotypeGeneColorectal Cancer Screening and DetectionGenetic factors in colorectal cancerGastric Cancer Management and Outcomes