Discovery of Semi- and Fully-Synthetic Carbohydrate Vaccines Against Bacterial Infections Using a Medicinal Chemistry Approach
Peter H. Seeberger
Abstract
, and other bacteria. The chemical tools described here help us gain fundamental insights into how the human system recognizes carbohydrates and drive the discovery of carbohydrate vaccines.
Topics & Concepts
ChemistryGlycocalyxGlycanImmune systemPolysaccharideConjugateCell wallCarbohydrateBacterial cell structureCellMicrobiologyConjugated systemBacteriaBiochemistryGlycoproteinImmunologyPolymerOrganic chemistryGeneticsBiologyMathematicsMathematical analysisCarbohydrate Chemistry and SynthesisBacteriophages and microbial interactionsAntibiotic Resistance in Bacteria