Reflections on a Principal of Research Ethics: Tom Beauchamp, Moral Specification, and Waivers of Informed Consent
Stephanie R. Morain, Luke Gelinas, David Wendler, P. Pearl O’Rourke, Emily A. Largent
Abstract
Tom Beauchamp's work is deeply woven into the field of bioethics. In this article, we honor Professor Beauchamp's pioneering contributions to research ethics, focusing on his seminal work articulating the key ethical principles that have become central to our understanding of research ethics scholarship and practice. We then examine how Professor Beauchamp's analytical framework of shared moral principles for research ethics can inform a contemporary ethics challenge: when can the requirements of informed consent permissibly be relaxed for research studies embedded into clinical care? We use this example both to illustrate how conceptual analysis and moral specification can inform the work of investigators, institutional review boards, and others charged with ensuring the ethical conduct of human subjects research, and to highlight where further conceptual work and practical guidance are needed.