Visible-Light-Induced, Palladium-Catalyzed Annulation of 1,3-Dienes to Construct Vinyl <i>N</i>-Heterocycles
Yu Zheng, Weidong Lu, Zhenzhen Xie, Kai Chen, Hao‐Yue Xiang, Hua Yang
Abstract
Herein, a photoinduced palladium-catalyzed annulation of 1,3-dienes with bifunctional halognated alkylamines has been developed, offering a facile route to access a broad range of vinylpyrrolidines. The reactivity profile of this protocol was able to be readily manipulated to assemble vinylpyrrolidine and vinlysilaazacycle. Remarkably, the utility of this strategy was further illustrated in the construction of complex and biologically important molecules as well as the diversity-oriented transformations of the resulting product.
Topics & Concepts
AnnulationChemistryPalladiumBifunctionalCatalysisReactivity (psychology)Combinatorial chemistryMoleculeOrganic chemistryPathologyMedicineAlternative medicineCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques