The c-Myc/miR-27b-3p/ATG10 regulatory axis regulates chemoresistance in colorectal cancer
Wu Sun, Jialu Li, Likun Zhou, Jiayi Han, Rui Liu, Haiyang Zhang, Tao Ning, Zhiying Gao, Baorui Liu, Xi Chen, Yi Ba
Abstract
: Our study identifies a novel c-Myc/miR-27b-3p/ATG10 signaling pathway that regulates colorectal cancer chemoresistance. These results suggest that miR-27b-3p is not only a potential indicator for evaluating efficiency of chemotherapy, but also a valuable therapeutic target for CRC, especially for patients with chemoresistance.
Topics & Concepts
Colorectal cancerCancer researchmicroRNACancerBiologyGeneGeneticsMicroRNA in disease regulationCancer-related molecular mechanisms researchCircular RNAs in diseases