Kidney-specific KO of the circadian clock protein PER1 alters renal Na<sup>+</sup> handling, aldosterone levels, and kidney/adrenal gene expression
Lauren G. Douma, Hannah M. Costello, G. Ryan Crislip, Kit‐Yan Cheng, I. Jeanette Lynch, Alexandria Juffre, Dominique Barral, Sarah Masten, Emilio Roig, Kevin Beguiristain, Wendy Li, Phillip Bratanatawira, Charles S. Wingo, Michelle L. Gumz
Abstract
For the first time, we show that knockout of the circadian clock transcription factor PERIOD 1 using kidney-specific cadherin Cre results in increased renal Na + reabsorption, increased aldosterone levels, and changes in gene expression in both the kidney and adrenal gland. Diurnal changes in renal Na + excretion were not observed, demonstrating that the clock protein PER1 in the kidney is important for maintaining homeostasis and that this effect may be independent of time of day.
Topics & Concepts
Internal medicineEndocrinologyPER1KidneyAldosteroneCircadian rhythmReabsorptionHomeostasisCLOCKBiologyRenal physiologyCircadian clockMedicineCircadian rhythm and melatoninGenetics, Aging, and Longevity in Model Organisms