Study of the aggregation, interaction, and thermodynamic properties of the dodecyltrimethylammonium bromide & cefixime trihydrate mixture in sodium salts solution at numerous temperatures
Md. Tuhinur R. Joy, Malik Abdul Rub, Md Al Amin Hossain, Provas Kumer Biswas, Yousef G. Alghamdi, Abdullah M. Asiri, Md. Ruhul Amin, Suman C. Mohanta, Md. Anamul Hoque, Shariff E. Kabir
Abstract
Cefixime trihydrate (CMT) has the usages to treat the bacterial infections of urinary tract, throat, ear & tonsils. Herein, the current investigation describes the interaction of CMT with dodecyltrimethylammonium Bromide (DTAB) by means of the conductivity measurement method in H2O and aq. solutions of NaBr, Na2SO4, and Na3PO4. The experiments were carried out at 310.55 K for several concentrations of CMT/ salts and temperatures of 300.55−320.55 K for one particular concentration of CMT/ salts employed. In every case, a single critical micelle concentration (CMC) has been achieved. The addition of CMT augments the aggregation of DTAB. The CMC values of the DTAB + CMT mixture undergo a decrease in attendance of electrolytes in comparison to water medium. In the manifestation of electrolytes, the CMC values of DTAB + CMT mixed systems at 310.55 K and ionic strength of 1 mmol kg−1 follow the order: CMC (H2O + NaBr) > CMC (H2O + Na2SO4) > CMC (H2O + Na3PO4). The negative ΔG°m values indicated that the micellization of DTAB + CMT mixture was spontaneous. The -ΔH°m and +ΔS°m values disclose that the assembly of DTAB + CMT mixture in aqueous medium is both enthalpy & entropy-controlled process. The thermodynamics of transfer and enthalpy-entropy compensation have also been described in the ongoing study.