Caesalpanins A–C, Three Dimeric Cassane Diterpenoids from the Seeds of <i>Caesalpinia sappan</i> L.
De‐Sheng Wang, Wei Nie, Tingting Jiang, Lin‐Fen Ding, Liu‐Dong Song, Xing‐De Wu, Qin‐Shi Zhao
Abstract
Abstract Three dimeric cassane diterpenoids, caesalpanins A–C, were isolated from the seeds of Caesalpinia sappan L., as well as three known compounds. Their structures were determined via analysis of 1D‐, 2D‐NMR, and HR‐ESI‐MS data. Caesalpanins A and B were the second and third compounds that presented a nitrogen‐containing cassane diterpenoid dimer linked through one ether bond between C‐19 and C‐20′. Caesalpanin B exhibited moderate cytotoxic activity against MCF‐7 cell lines with IC 50 value of 29.98 μ m . Caesalpanins A and B had weak inhibitory effects against LPS‐induced nitric oxide (NO) production in RAW 264.7 macrophages at 50 μ m with inhibitory rate of 36.01 % and 32.93 %, respectively.