Catalytic enantioselective synthesis of indolizino[8,7-<i>b</i>]indole alkaloid derivatives based on the tandem reaction of tertiary enamides
Xin‐Ming Xu, Ming Xie, Jiazhu Li, Mei‐Xiang Wang
Abstract
An exquisite Pybox/Cu(OTf)<sub>2</sub>-catalyzed asymmetric tandem reaction of tertiary enamides was developed, which enabled the expeditious synthesis of indolizino[8,7-<italic>b</italic>]indole derivatives in high yield, excellent enantioselectivity and diastereoselectivity.
Topics & Concepts
ChemistryEnantioselective synthesisTandemIndole testYield (engineering)CatalysisIndole alkaloidStereochemistryAlkaloidCascade reactionCombinatorial chemistryOrganic chemistryComposite materialMetallurgyMaterials scienceChemical synthesis and alkaloidsAlkaloids: synthesis and pharmacologyCyclopropane Reaction Mechanisms