Ferumoxytol-β-glucan Inhibits Melanoma Growth via Interacting with Dectin-1 to Polarize Macrophages into M1 Phenotype
Xinghan Liu, Yujun Xu, Yi Li, Yuchen Pan, Shuli Zhao, Yayi Hou
Abstract
Background: Regulating the polarization of macrophages to antitumor M1 macrophages is a promising strategy for overcoming the immunosuppression of the tumor microenvironment for cancer therapy. Ferumoxytol (FMT) can not only serve as a drug deliver agent but also exerts anti-tumor activity. -glucan has immuno-modulating properties to prevent tumor growth. Thus, a nanocomposite of FMT surface-coated with -glucan (FMT--glucan) was prepared to explore its effect on tumor suppression.
Topics & Concepts
Flow cytometryGlucanApoptosisViability assayTransfectionChemistryAnnexinMolecular biologyTumor microenvironmentCancer researchBiologyBiochemistryTumor cellsGeneHistone Deacetylase Inhibitors ResearchImmune cells in cancerCancer Cells and Metastasis