Catalyst‐Free, Heating‐Induced Desulfurization Annulation of CF<sub>3</sub>‐Imidoyl Sulfoxonium Ylides with Isothiocyanates for the Synthesis of 2‐Trifluoromethyl‐4‐aminoquinolines
Guangming Wei, Yue Sun, Dongling Zheng, Shiqi Qiu, Zhengkai Chen, Xiao‐Feng Wu
Abstract
Abstract A heating‐induced desulfurization annulation of readily available CF 3 ‐imidoyl sulfoxonium ylides and isothiocyanates for the construction of 2‐trifluoromethylquinolines has been achieved. The developed transformation was performed under metal‐ and additive‐free conditions, producing a variety of biologically valuable 2‐trifluoromethylquinoline derivatives with high efficiency.
Topics & Concepts
AnnulationChemistryFlue-gas desulfurizationTrifluoromethylCatalysisCombinatorial chemistryOrganic chemistryAlkylFluorine in Organic ChemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods