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Targeted Augmentation of Nuclear Gene Output (TANGO) of Scn1a rescues parvalbumin interneuron excitability and reduces seizures in a mouse model of Dravet Syndrome

Eric R. Wengert, Pravin K. Wagley, Samantha M. Strohm, Nuha Reza, Ian C. Wenker, Ronald P. Gaykema, Anne Christiansen, Gene Liau, Manoj K. Patel

2021Brain Research61 citationsDOI

Topics & Concepts

Dravet syndromeInterneuronParvalbuminInhibitory postsynaptic potentialNeuroscienceEpilepsyBiologySodium channelMedicineEndocrinologyChemistrySodiumOrganic chemistryNeurogenetic and Muscular Disorders ResearchGenetics and Neurodevelopmental DisordersRNA Research and Splicing
Targeted Augmentation of Nuclear Gene Output (TANGO) of Scn1a rescues parvalbumin interneuron excitability and reduces seizures in a mouse model of Dravet Syndrome | Litcius