Nanocarriers Provide Sustained Antifungal Activity for Amphotericin B and Miltefosine in the Topical Treatment of Murine Vaginal Candidiasis
Fernanda Walt Mendes da Silva de Bastiani, Cristina de Castro Spadari, Jenyffer K.R. de Matos, Giovanna Cassone Salata, Luciana B. Lopes, Kelly Ishida
Abstract
imaging showed that nanocarriers allowed prolonged antifungal activity by intravaginal administration reducing drug administration frequency. Therefore, AMB and MFS incorporated into a microemulsion and MFS encapsulated in alginate nanoparticles could be effective therapeutic alternatives for vaginal candidiasis, likely due to the sustained antifungal activity provided by these nanocarriers.
Topics & Concepts
MiltefosineAntifungalAmphotericin BVulvovaginal CandidiasisPhosphorylcholineMedicinePharmacologyMicrobiologyCandida albicansVaginitisBiologyDermatologyImmunologyLeishmaniasisVisceral leishmaniasisBiochemistryGynecologyAntifungal resistance and susceptibilityMedical and Biological Ozone ResearchAntimicrobial Peptides and Activities