Structural basis for the design of bisubstrate inhibitors of protein kinase CK2 provided by complex structures with the substrate-competitive inhibitor heparin
Alexander Schnitzler, Karsten Niefind
Topics & Concepts
ChemistryStereochemistrySubstrate (aquarium)Binding siteNon-competitive inhibitionHeparinMonoclinic crystal systemKinaseBiochemistryEnzymeCrystal structureCrystallographyBiologyEcologyProtein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancerCarbohydrate Chemistry and Synthesis