Glioblastoma: Relationship between Metabolism and Immunosuppressive Microenvironment
Ainhoa Hernández, Marta Doménech, Ana M Muñoz‐Mármol, Cristina Carrato, Carmen Balañá
Abstract
Glioblastoma (GBM) is the most aggressive brain tumor in adults and is characterized by an immunosuppressive microenvironment. Different factors shaping this tumor microenvironment (TME) regulate tumor initiation, progression, and treatment response. Genetic alterations and metabolism pathways are two main elements that influence tumor immune cells and TME. In this manuscript, we review how both factors can contribute to an immunosuppressive state and overview the strategies being tested.
Topics & Concepts
Tumor microenvironmentGlioblastomaImmune systemCancer researchTumor progressionBiologyBrain tumorImmunologyMedicineCancerPathologyGeneticsGlioma Diagnosis and TreatmentImmune cells in cancerHistone Deacetylase Inhibitors Research