Tumor organoid model of colorectal cancer (Review)
Chi Yang, Wangwen Xiao, Rui Wang, Yan Hu, Ke Yi, Xuan Sun, Guanghui Wang, Xiaohui Xu
Abstract
The establishment of self‑organizing ‘mini‑gut’ organoid models has brought about a significant breakthrough in biomedical research. Patient‑derived tumor organoids have emerged as valuable tools for preclinical studies, offering the retention of genetic and phenotypic characteristics of the original tumor. These organoids have applications in various research areas, including <em>in vitro</em> modelling, drug discovery and personalized medicine. The present review provided an overview of intestinal organoids, focusing on their unique characteristics and current understanding. The progress made in colorectal cancer (CRC) organoid models was then delved into, discussing their role in drug development and personalized medicine. For instance, it has been indicated that patient‑derived tumor organoids are able to predict response to irinotecan‑based neoadjuvant chemoradiotherapy. Furthermore, the limitations and challenges associated with current CRC organoid models were addressed, along with proposed strategies for enhancing their utility in future basic and translational research.14