Mycolic acid-containing bacteria trigger distinct types of membrane vesicles through different routes
Toshiki Nagakubo, Yuhei O. Tahara, Makoto Miyata, Nobuhiko Nomura, Masanori Toyofuku
Abstract
form distinct types of MVs via different routes in response to environmental conditions. DNA-damaging stress induced MV formation through prophage-triggered cell lysis, whereas envelope stress induced MV formation through mycomembrane blebbing. The MV formation routes were conserved in other mycolic acid-containing bacteria. Our results show how the complex cell envelope structure intrinsically generates various types of MVs and will advance our knowledge on how different types of MVs can be generated from a single cell organism.
Topics & Concepts
Cell envelopeCorynebacterium glutamicumBacteriaMycolic acidBacterial cell structureLysisChemistryBiologyCell biologyCellBiophysicsBiochemistryGeneticsEscherichia coliMycobacteriumGeneBacterial Infections and VaccinesBacteriophages and microbial interactionsExtracellular vesicles in disease