Isopropyl Amino Acid Esters Ionic Liquids as Vehicles for Non-Steroidal Anti-Inflammatory Drugs in Potential Topical Drug Delivery Systems with Antimicrobial Activity
Joanna Klebeko, Oliver Krüger, Mateusz Dubicki, Paula Ossowicz‐Rupniewska, Ewa Janus
Abstract
New derivatives of non-steroidal anti-inflammatory drugs were synthesized via conjugation with L-amino acid isopropyl esters. The characteristics of the physicochemical properties of the obtained pharmaceutically active ionic liquids were determined. It has been shown how the incorporation of various L-amino acid esters as an ion pair affects the properties of the parent drug. Moreover, the antimicrobial activity of the obtained compounds was evaluated. The proposed structural modifications of commonly used drugs indicate great potential for use in topical and transdermal preparations.
Topics & Concepts
TransdermalIsopropylChemistryAntimicrobialIsopropyl myristateDrugAmino acidDrug deliveryIonic liquidCombinatorial chemistryOrganic chemistryPharmacologyBiochemistryMedicineCatalysisPharmacological Effects of Natural CompoundsEssential Oils and Antimicrobial ActivityAdvancements in Transdermal Drug Delivery