Aberrant activation of the CD45-Wnt signaling axis promotes stemness and therapy resistance in colorectal cancer cells
So‐Yeon Park, Ji Young Kim, Gyu-Beom Jang, Jang-Hyun Choi, Jee‐Heun Kim, Choong-Jae Lee, Sunjae Lee, Jeong‐Heum Baek, Kwan‐Kyu Park, Jin‐Man Kim, Hee Jin Chang, Nam‐Chul Cho, Jeong‐Seok Nam
Abstract
Our results highlight a novel function of CD45 as a mediator of CRT resistance and provide a potential therapy strategy for CRC therapy.
Topics & Concepts
Wnt signaling pathwayCancer researchCancer stem cellMetastasisColorectal cancerCancerCancer cellBiologyMedicineSignal transductionInternal medicineCell biologyCancer Cells and MetastasisCancer-related molecular mechanisms researchCancer, Stress, Anesthesia, and Immune Response