Systemic overexpression of C-C motif chemokine ligand 2 promotes metabolic dysregulation and premature death in mice with accelerated aging
Fedra Luciano‐Mateo, Noemí Cabré, Gerard Baiges‐Gayà, Salvador Fernández‐Arroyo, Anna Hernández‐Aguilera, Elisabet Rodríguez‐Tomàs, Meritxell Arenas, Jordi Camps, Javier A. Menéndez, Jorge Joven
Abstract
to promote death in mice with accelerated aging, which supports its putative use as a biomarker of an increased senescent cell burden and for the assessment of the efficacy of interventions aimed at extending healthy aging.
Topics & Concepts
ChemokineMotif (music)ImmunologyBiologyCell biologyInflammationPhilosophyAestheticsNeuroinflammation and Neurodegeneration Mechanisms