ElyC and Cyclic Enterobacterial Common Antigen Regulate Synthesis of Phosphoglyceride-Linked Enterobacterial Common Antigen
Ashutosh K. Rai, Joseph F. Carr, David E. Bautista, Wei Wang, Angela M. Mitchell
Abstract
Enterobacterial common antigen (ECA) is a conserved polysaccharide present on the surface of the outer membrane (OM) and in the periplasm of the many pathogenic bacteria belonging to Enterobacterales , including Klebsiella pneumoniae , Salmonella enterica , and Yersinia pestis . As the OM is a permeability barrier that excludes many antibiotics, synthesis pathways for OM molecules are promising targets for antimicrobial discovery.
Topics & Concepts
Periplasmic spacePeptidoglycanBacterial outer membraneBiosynthesisEscherichia coliCell envelopeBiochemistryBiologyMutantPhosphodiester bondChemistryCell biologyBacterial cell structureAntigenCell wallCell membraneMembrane proteinBacteriaInner membraneGeneProtein structureGlycosyltransferaseMicrobiologyBacterial adhesinProtein biosynthesisImmunoprecipitationIn silicoEscherichia coli research studiesBacterial Genetics and BiotechnologyYersinia bacterium, plague, ectoparasites research