Dual targeting of CTLA-4 and CD47 on T <sub>reg</sub> cells promotes immunity against solid tumors
Anli Zhang, Zhenhua Ren, Kuo‐Fu Tseng, Xiaojuan Liu, Huiyu Li, Changzheng Lu, Yueqi Cai, John D. Minna, Yang‐Xin Fu
Abstract
Selective CD47 blockade on CTLA-4 high tumor-infiltrating T reg cells reduces systemic toxicity and enhances antitumor immunity.
Topics & Concepts
CD47ImmunityCancer researchSolid tumorChemistryImmunologyBiologyMedicineImmune systemCancerInternal medicineImmune Cell Function and InteractionPhagocytosis and Immune RegulationImmunotherapy and Immune Responses