Post-vaccine COVID-19 in patients with multiple sclerosis or neuromyelitis optica
Édouard Januel, de Sèze, Patrick Vermersch, Elisabeth Maillart, Bertrand Bourre, Julie Pique, Xavier Moisset, Caroline Bensa, Adil Maarouf, Jean Pelletier, Sandra Vukusic, Bertrand Audoin, Céline Louapre, S. Beltran, Éric Berger, Kévin Bigaut, Nathalie Derache, Salimata Gassama, Olivier Heinzlef, Laurent Kremer, Philippe Kerschen, Aude Maurousset, Vito A. G. Ricigliano, P.-Y. Garcia, Pierre Labauge
Abstract
INTRODUCTION: Recent studies suggested that anti-CD20 and fingolimod may be associated with lower anti-spike protein-based immunoglobulin-G response following COVID-19 vaccination. We evaluated if COVID-19 occurred despite vaccination among patients with multiple sclerosis (MS) and neuromyelitis optica (NMO), using the COVISEP registry. CASE SERIES: We report 18 cases of COVID-19 after two doses of BNT162b2-vaccination, 13 of which treated with anti-CD20 and four with fingolimod. COVID-19 severity was mild. DISCUSSION: These results reinforce the recommendation for a third COVID-19 vaccine dose among anti-CD20 treated patients and stress the need for a prospective clinical and biological study on COVID-19 vaccine efficacy among MS and NMO patients.