Structure of the Reductase Domain of a Fungal Carboxylic Acid Reductase and Its Substrate Scope in Thioester and Aldehyde Reduction
Bastian Daniel, Chiam Hashem, Marlene Leithold, Theo Sagmeister, Adrian Tripp, Holly Stolterfoht, Julia Messenlehner, Ronan M. Keegan, Christoph K. Winkler, Jonathan Guyang Ling, Sabry H. H. Younes, Gustav Oberdorfer, Farah Diba Abu Bakar, Karl Gruber, Tea Pavkov‐Keller, Margit Winkler
Abstract
CAR reduced aldehydes to primary alcohols. In conclusion, aldehyde overreduction can no longer be attributed exclusively to the host background.
Topics & Concepts
AldehydeCarboxylic acidChemistryThioesterReductaseKetoneStereochemistryNeurospora crassaSubstrate (aquarium)Combinatorial chemistryEnzymeOrganic chemistryBiochemistryCatalysisBiologyEcologyGeneMutantMicrobial Metabolic Engineering and BioproductionEnzyme Catalysis and ImmobilizationBiofuel production and bioconversion