Mesenchymal stem cell-derived extracellular vesicles targeting irradiated intestine exert therapeutic effects
Ningning He, Mingxin Dong, Yuxiao Sun, Mengmeng Yang, Yan Wang, Liqing Du, Kaihua Ji, Jinhan Wang, Manman Zhang, Yeqing Gu, Xinran Lu, Yang Liu, Qin Wang, Zongjin Li, Huijuan Song, Chang Xu, Qiang Liu
Abstract
MSC-EVs can dose-dependently target radiation-injured intestinal tissues, allow a spatiotemporal diagnosis in different degrees of damage to help guide personalized therapy, offer data for designing EV-based theranostic strategies for promoting recovery from radiation-induced intestinal injury, and provide cell-free treatment for radiation therapy.
Topics & Concepts
Mesenchymal stem cellExtracellular vesiclesExtracellularCell biologyCellChemistryVesicleSmall intestineCancer researchStem cellBiologyBiochemistryMembraneExtracellular vesicles in diseaseTissue Engineering and Regenerative Medicine