Lactate dehydrogenase B regulates macrophage metabolism in the tumor microenvironment
Ann-Christin Frank, Rebecca Raue, Dominik C. Fuhrmann, Evelyn Sirait‐Fischer, Carsten Reuse, Andreas Weigert, Dieter Lütjohann, Karsten Hiller, Shahzad N. Syed, Bernhard Brüne
Abstract
: Our findings identified a crucial role of LDHB in macrophages and established tumor-derived miR-375 as a novel regulator of macrophage metabolism in breast cancer, which might pave the way for strategies of combinatorial cancer cell/stroma cell interventions.
Topics & Concepts
Tumor microenvironmentDownregulation and upregulationCancer researchStromal cellChemistryTumor progressionMacrophageGene knockdownCancer cellBiologyCancerApoptosisBiochemistryGeneGeneticsIn vitroTumor cellsCancer, Lipids, and MetabolismCancer, Hypoxia, and MetabolismImmune cells in cancer