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Design, synthesis, and biological evaluation of 1-methyl-1H-pyrazolo[4,3-b]pyridine derivatives as novel small-molecule inhibitors targeting the PD-1/PD-L1 interaction

Xinyan Dai, Ke Wang, Hao Chen, Xupeng Huang, Zhiqiang Feng

2021Bioorganic Chemistry28 citationsDOI

Topics & Concepts

ChemistryJurkat cellsSmall moleculeIC50DimerStereochemistryPyridineDocking (animal)Monoclonal antibodyT cellIn vitroBiochemistryAntibodyImmune systemBiologyMedicineImmunologyOrganic chemistryMedicinal chemistryNursingCAR-T cell therapy researchCancer Immunotherapy and BiomarkersMelanoma and MAPK Pathways
Design, synthesis, and biological evaluation of 1-methyl-1H-pyrazolo[4,3-b]pyridine derivatives as novel small-molecule inhibitors targeting the PD-1/PD-L1 interaction | Litcius