T Cell Cytokines Impact Epithelial Cell Responses during <i>Helicobacter pylori</i> Infection
Holly M. Scott Algood
Abstract
Abstract The goal of this Brief Review is to highlight literature that demonstrates how cytokines made by T lymphocytes impact the gastric epithelium, especially during Helicobacter pylori infection. These cytokines effect many of the diverse functions of the epithelium and the epithelium’s interactions with H. pylori. The focal point of this Brief Review will be on how T cell cytokines impact antimicrobial function and barrier function and how T cell cytokines influence the development and progression of cancer. Furthermore, the modulation of epithelial-derived chemokines by H. pylori infection will be discussed.
Topics & Concepts
Helicobacter pyloriChemokineEpitheliumImmunologyBarrier functionProinflammatory cytokineBiologyCytokineFunction (biology)CellImmune systemInflammationCell biologyGeneticsHelicobacter pylori-related gastroenterology studiesGalectins and Cancer BiologyEosinophilic Esophagitis