Bioinspired NiO Nanospheres: Exploring <i>In Vitro</i> Toxicity Using Bm-17 and <i>L. rohita</i> Liver Cells, DNA Degradation, Docking, and Proposed Vacuolization Mechanism
Prashant B. Chouke, Ajay K. Potbhare, Nitin P. Meshram, M. Manoj, Kanhaiya M. Dadure, Karan Chaudhary, R. Alok, Martín F. Desimone, Ratiram Gomaji Chaudhary, Dhanraj T. Masram
Abstract
liver cells was studied. No toxicity was observed at 1 mg/L of NiO NPs; however, when the concentration was 30 and 90 mg/L, dark and shrank hepatic parenchyma was observed. Hence, the main cause of cell lysis is the increased vacuolization in the cells. Thus, the present study suggests that the cytotoxicity induced by NiO NPs could be used in anticancer drugs.
Topics & Concepts
X-ray photoelectron spectroscopyNon-blocking I/OFourier transform infrared spectroscopyRaman spectroscopyNuclear chemistryScanning electron microscopeMaterials scienceSpectroscopyChemistryAnalytical Chemistry (journal)Chemical engineeringNanotechnologyBiochemistryOrganic chemistryQuantum mechanicsOpticsEngineeringPhysicsComposite materialCatalysisNanoparticles: synthesis and applicationsAdvanced Nanomaterials in CatalysisLaser-Ablation Synthesis of Nanoparticles