Injectable Diels–Alder cycloaddition hydrogels with tuneable gelation, stiffness and degradation for the sustained release of T-lymphocytes
Jie Yan, Batjargal Gundsambuu, Marta Krasowska, Kirsten Platts, Paula Facal Marina, Cobus Gerber, Simon C. Barry, Anton Blencowe
Abstract
Highly efficient, selective and cytocompatible fulvene–maleimide cycloaddition chemistry was applied for the preparation of injectable, cell encapsulating/releasing hydrogels with tuneable gelation and degradation kinetics.
Topics & Concepts
Self-healing hydrogelsMaterials scienceEthylene glycolConjugated systemCycloadditionChemical engineeringPolymerPolymer chemistryChemistryOrganic chemistryComposite materialCatalysisEngineeringCAR-T cell therapy researchMonoclonal and Polyclonal Antibodies ResearchImmunotherapy and Immune Responses